SHVM

20th Annual Scientific Sessions:

Cardiovascular disease in the metabolic syndrome: Linking metabolism, inflammation and heart disease

Graz, Austria 25-28 June 2023

SHVM

20th Annual Scientific Sessions:

Cardiovascular disease in the metabolic syndrome: Linking metabolism, inflammation and heart disease

Graz, Austria 25-28 June 2023

Graz, Austria
25-28 June 2023

Programme

  • 10:00-18:00

    Registration

    Trainee Workshop

    Chairs: Susanne Sattler (Graz, Austria), Michael Schwarzer (Jena, Germany)

    15:00-15:45

    Single cell technologies

    Holger Winkels (Cologne, Germany)

    15:45-17:15

    In vivo models of cardiovascular disease

    Dimitris Tsiantoulas (Vienna, Austria)
    Atherosclerosis and myocardial infarction

    Nikole Byrne (Graz, Austria)
    Models of diabetes and metabolic stress

    Opening Session

    18:00-18:15

    Welcome from Organisers and SHVM President

    18:15-19:15

    Keynote Lecture

    Chairs: Andreas Zirlik (Graz, Austria), Christian Schulze (Jena, Germany)

    Christoph Binder (Vienna, Austria)
    Extracellular vesicles as mediators in cardiovascular disease

    19:15

    Informal dinner reception

  • Session 1 – Cardiovascular treatment targets in the metabolic syndrome

    Chairs: Irene Lang (Vienna, Austria), Kieran Clarke (Oxford, United Kingdom)

    8:15-8:45

    Harald Sourij (Graz, Austria)
    Mechanisms of cardioprotection by GLP-1 agonism

    8:45-9:15

    Coert Zuurbier (Amsterdam, The Netherlands)
    Vascular and myocardial effects of SGLT2 inhibition

    9:15-9:45

    Gregory Shearer (University Park, PA, USA)
    Risk reduction by omega-3 fatty acids: fact or fiction?

    9:45-10:00

    Short talk: Jaetaek Kim (Seoul, South Korea)
    Insulin signaling is critical for sinoatrial node maintenance and function

    10:00-10:30

    Coffee break

    10:30-11:00

    Jingyuan Fu (Groningen, The Netherlands)
    Microbiome, metabolome and cardiovascular health

    11:00-11:30

    Kurt Huber (Vienna, Austria)
    Treatment strategies targeting lipoproteins and cholesterol

    11:30-11:45

    Short talk: Bellina Mushala (Pittsburgh, PA, USA)
    GPR19 is an orphan receptor that mediates cardio-hepatic metabolic crosstalk in obesity

    11:45-12:00

    Short talk: Chloé David (Montréal, Canada)
    The benefit of B vitamins in female heart function and survival in a mice model of heart failure involves cardiac and pulmonary fibrosis improvement and preserved circulating lipidome remodeling

    12:00-13:00

    Lunch Symposium (sponsored by Abbott)

    Chairs: Andreas Zirlik (Graz, Austria), Daniel Zimpfer (Graz, Austria)

    Stefan Harb (Graz, Austria)
    Intravascular imaging – news from OCT

    Martin Benedikt (Graz, Austria)
    The concept of fusion stimulation - SyncAV+CRT

    Albrecht Schmidt (Graz, Austria)
    How will be the future of combined AV-Therapy?

    13:00-13:30

    Break

    Session 2 – Inflammation and immunity in myocardial and vascular disease

    Chairs: Dennis Wolf (Freiburg, Germany), Judy de Haan (Melbourne, Australia)

    13:30-14:00

    Wei Liu (Manchester, UK)
    Linking cardiomyocyte stress with inflammation in the diabetic heart

    14:00-14:30

    Pilar Alcaide (Boston, MA, USA)
    T cells in myocardial disease: friend or foe?

    14:30-14:45

    Short talk: Joost Luiken (Maastricht, The Netherlands)
    Activating v-ATPase ameliorates lipid-induced cardiomyopathy by repressing the CD36–TLR4 axis

    14:45-15:30

    Special Lecture

    Jean-Claude Tardif (Montreal, Canada)
    Antiinflammatory therapy with colchicine: ready for prime time?

    15:30-16:00

    Coffee break

    Session 3 – The "William C. Stanley" Early Investigator Award

    Chairs: Heiko Bugger (Graz, Austria), Jaetaek Kim (Seoul, South Korea)

    16:00-16:15

    Sasha Smolgovsky (Boston, MA, USA)
    Dysregulation of the IRE1α-XBP1s axis directs T cell inflammation in experimental Heart Failure with Preserved Ejection Fraction (HFpEF)

    16:15-16:30

    Stephanie Anderson (Oxford, United Kingdom)
    Multiparametric immunometabolic phenotyping of the diabetic heart

    16:30-16:45

    Lorenz Holzner (Cambridge, United Kingdom)
    Liver specific HIF2α deletion modulates hepatic and cardiac mitochondrial function in a model of non-alcoholic fatty liver disease

    16:45-17:00

    Yung-Ting Hsiao (Osaka, Japan)
    Circulating obesity associated pro-fibrotic protein as a brown adipokine promotes fibrosis in liver and heart

    17:00-18:00

    Evening symposium (sponsored by Novartis)
    Doctors Voice, Patient Choice - From Traditional Therapy to Innovative Therapy!

    Chair: Andreas Zirlik (Graz, Austria)

    Heinz Drexel (Feldkirch, Austria), Thomas Stulnig (Vienna, Austria)
    Why is it so hard to reach LDL-C targets – a reality check

    Dietmar Hubner (Wels, Austria), Harald Sourij (Graz, Austria)
    Inclisiran – a game changer for target control

    All
    Lipid- and cardiovascular high risk management of the future – quo vadis?

    18:00-19:30

    Poster Session I & Exhibitions

    19:30

    Dinner

  • Session 4 – Nutrients and diet in cardiometabolic disease

    Chairs: Adam Wende (Birmingham, AL, USA), Lisa Heather (Oxford, United Kingdom)

    8:30-9:00

    Thomas Pulinilkunnil (St. John, Canada)
    BCAA metabolism in cardiac disease

    9:00-9:30

    Bettina Mittendorfer (St. Louis, MO, USA)
    Nutrient supplementation and cardiometabolic risk

    9:30-10:00

    Hyoung Kyu Kim (Busan, South Korea)
    BH4 supplementation in the regulation of cardiac energetics

    10:00-10:30

    Coffee break

    10:30-11:00

    Guenter Haemmerle (Graz, Austria)
    Lipids regulating mitochondrial integrity in the heart

    11:00-11:30

    Asa B. Gustafsson (San Diego, CA, USA)
    Mitochondrial quality control in the heart

    11:30-11:45

    Short talk: Shubham Soni (Edmonton, Canada)
    Gestational ketone supplementation during perinatal iron deficiency may protect against cardiac damage in the neonatal offspring

    11:45-12:00

    Short talk: Matthew Rochowski (Stillwater, OK, USA)
    Cardiac-specific SERCA overexpression improves cardiac and systemic glucose metabolism during diabetes

    12:00-13:00

    Lunch break

    13:00-14:00

    Poster Session II & Exhibitions

    Session 5 – Metabolic disease and cardiovascular inflammation

    Chairs: Linda Peterson (Saint Louis, MO, USA), Christoph Binder (Vienna, Austria)

    14:00-15:00

    Keynote Lecture

    Paul Ridker (Boston, MA, USA)
    Antiniflammatory therapy in cardiovascular disease

    15:00-15:30

    Dennis Wolf (Freiburg, Germany)
    Dysmetabolism driving cardiovascular inflammation

    15:30-15:45

    Coffee break

    15:45-16:15

    Judy De Haan (Melbourne, Australia)
    Inflammasome in diabetic heart disease

    16:15-17:05

    Evening symposium (sponsored by Novo Nordisk)
    Targeting inflammation in type 2 diabetes and ASCVD – from science into practice

    Chair: Heiko Bugger (Graz, Austria)

    Andreas Zirlik (Graz, Austria)
    Inflammation in the cardiometabolic continuum and therapeutic considerations

    Harald Sourij (Graz, Austria)
    GLP-1 RA in diabetes and obesity: implementing science into practice

    17:05-17:15

    Talk sponsored by Ablative Solutions

    Heiko Bugger (Graz, Austria)
    Renal Denervation by alcohol-mediated neurolysis using the Peregrine Infusion Catheter

    17:30-19:00

    Networking activity

    20:00

    Dinner

  • 8:30-9:30

    "William C. Stanley" Award Lecture

    Chair: E. Dale Abel (Los Angeles, CA, USA)

    Christine Des Rosiers (Montreal, Canada)
    Metabolomic signatures and cardiovascular disease

    Session 6 – Dysregulated energy metabolism in heart failure

    Chairs: Veronique Lacombe (Stillwater, OK, USA), Simon Sedej (Graz, Austria)

    9:30-10:00

    Senka Holzer (Graz, Austria)
    Perinuclear mitochondria in heart disease

    10:00-10:15

    Short talk: Petra Kienesberger (Saint John, Canada)
    Effect of cardiomyocyte-specific lipid phosphate phosphatase 3 (LPP3) overexpression on energy metabolism and metabolic cardiomyopathy

    10:15-10:45

    Coffee break

    10:45-11:15

    Christoph Maack (Würzburg, Germany)
    Mechanoenergetic defects in heart failure

    11:15-11:45

    Gabriele Schiattarella (Berlin, Germany)
    Cardiometabolic mechanisms in HFpEF

    11:45-12:00

    Short talk: Marine De Loof (Brussels, Belgium)
    Acetylation of α-tubulin, a new player in cardiac glucose transport

    12:00-12:10

    Invitation to SHVM 2024

    12:10-12:20

    Concluding Remarks

    Organisers and SHVM President

    12:20

    Buffet Lunch

  • When preparing your poster, please remember that its maximum size is A0 (841 x 1189 mm; width x height). Note that the orientation is portrait, not landscape.

    Correct format... poster should be PORTRAIT  poster should NOT be LANDSCAPE Wrong format...

    You are expected to have your poster up the latest by lunchtime of the day of your session. Posters should be taken down after your session. Posters left behind will be removed and discarded by the venue personnel.

    Poster presenters are required to be available for discussion during their assigned session. The distribution of posters in the two sessions is indicated below.

    • Poster Session I • Monday 26 June • 18:00

      P1.1 · Stephanie Anderson (Oxford, United Kingdom)
      Multiparametric immunometabolic phenotyping of the diabetic heart

      P1.2 · Melina Amor (Graz, Austria)
      Investigating the effects of MMP12 deficiency in cardiometabolic diseases

      P1.3 · Michael G Atser (Vancouver, Canada)
      The role of pyruvate dehydrogenase kinase 1 in triacylglycerol metabolism in differentiated H9C2 cardiomyocytes

      P1.4 · Sun Sik Bae (Yangsan, South Korea)
      Phospholipase C-β3 regulates vascular hyperplasia by the modulation of redox status

      P1.5 · Neoma T Boardman (Tromsø, Norway)
      Cardiac mitochondrial morphological and bioenergetic changes following breast cancer treatment

      P1.6 · David Yin Cai (Hong Kong, China)
      Knockdown of Hspa1b aggravates hypoxia/reoxygenation-induced cell injury and apoptosis via activation of p53 in H9C2 cardiomyocytes

      P1.7 · Chloé David (Montreal, Canada)
      The benefit of B vitamins in female heart function and survival in a mice model of heart failure involves cardiac and pulmonary fibrosis improvement and preserved circulating lipidome remodeling

      P1.8 · Marine De Loof (Brussels, Belgium)
      Acetylation of α-tubulin, a new player in cardiac glucose transport

      P1.9 · Johannes Gollmer (Graz, Austria)
      Molecular alterations of human diabetic heart disease revealed using single nucleus RNA sequencing

      P1.10 · Stefan Groß (Greifswald, Germany)
      The association between C24:0/C16:0 ceramide ratio and cardiorespiratory fitness is robust to effect modifications by age and sex in the general population: Results from the Study of Health in Pomerania (SHIP-START-1), Germany

      P1.11 · Estelle Heyne (Jena, Germany)
      Mitochondrial DNA differences in rats with high or low genetically determined exercise capacity affect cardiac function and metabolism

      P1.12 · Lorenz M. W. Holzner (Cambridge, United Kingdom)
      Liver specific HIF2α deletion modulates hepatic and cardiac mitochondrial function in a model of non-alcoholic fatty liver disease

      P1.13 · Yung-Ting Hsiao (Osaka, Japan)
      Circulating obesity associated pro-fibrotic protein as a brown adipokine promotes fibrosis in liver and heart

      P1.14 · Guihwa Jeong (Gumi, South Korea)
      NQO1-mediated activation of AMPK prevents diet-induced obesity and related complications

      P1.15 · Agnieszka Karaś (Cracow, Poland)
      The effect of vascular ageing and dyslipidaemia on vascular metabolism, endothelial function and arterial stiffness

      P1.16 · Petra Kienesberger (Saint John, Canada)
      Effect of cardiomyocyte-specific lipid phosphate phosphatase 3 (LPP3) overexpression on energy metabolism and metabolic cardiomyopathy

      P1.17 · Mi Kyung Kim (Daegu, South Korea)
      Metabolic switching from glycolysis to oxidative phosphorylation by PDH in macrophage ameliorates atherosclerosis by suppressing iNOS-induced foam cell formation

      P1.18 · Katarzyna Kmiotek (London, United Kingdom)
      Role of phosphofructokinase P ​in cardiac hypertrophy 

      P1.19 · Azra Kulovic-Sissawo (Graz, Austria)
      Circulating neprilysin in pregnancy

      P1.20 · Wei Li (Tromsø, Norway)
      Fatty acids from Calanus oil-derived wax ester stimulate fatty acid oxidation and prevent palmitate-induced cell death

      P1.21 · Yongwoon Lim (Hwasun-gun, South Korea)
      The role of acetyltransferase PCAF in cardiac remodeling

      P1.22 · Alice Marino (Brussels, Belgium)
      Sodium myo-inositol cotransporter 1 affects cardiac hypertrophy in pressure-overloaded mouse hearts

      P1.23 · Olurotimi O Mesubi (Baltimore, MD, USA)
      Identifying transcriptomic changes that link O-GlcNAcylation to hyperglycemia-primed atrial fibrillation

      P1.24 · Eun-Ji Min (Seoul, South Korea)
      Porphyromonas gingivalis infection accelerates atherosclerosis through inducing oral and intestinal in western-fed murine model

      P1.25 · Akiyuki Nishimura (Okazaki, Japan)
      Sulfide metabolism has principal roles in ischemic resistance of the heart

      P1.26 · Jeanne Pottien (Greifswald, Germany)
      Individual trajectories of cardiorespiratory fitness (VO2max) over time - An underrated predictor of all-cause mortality? Joint modeling of longitudinal and survival data over several follow-ups of the Study of Health in Pomerania (SHIP-START) in Germany

      P1.27 · Christina M. Reumiller (London, United Kingdom)
      Regulation of cardiac glucose intermediary metabolism by c-Myc during exercise

      P1.28 · Marcel Rose (Jena, Germany)
      Atrial mitochondrial respiratory chain complex activity in human hearts differs from ventricular and septal activities

      P1.29 · Lukas Schönbacher (Graz, Austria)
      Associations of prenatal human milk oligosaccharides (HMOs) with maternal BMI and lipid profile in overweight and obese pregnant women

      P1.30 · Abhipree Sharma (Parkville, Australia)
      Sex differences in the cardiometabolic phenotype of mice – impact of high fat diet and the SGLT2i, dapagliflozin

      P1.31 · Sasha A Smolgovsky (Boston, MA, USA)
      Dysregulation of the IRE1α-XBP1s axis directs T cell inflammation in experimental Heart Failure with Preserved Ejection Fraction (HFpEF)

      P1.32 · Shubham Soni (Edmonton, Canada)
      Gestational ketone supplementation during perinatal iron deficiency may protect against cardiac damage in the neonatal offspring

      P1.33 · Fang Wang (Maastricht, Netherlands)
      Quercetin ameliorates insulin-stimulated glucose uptake in a cardiomyocyte model of lipid overload

      P1.34 · Elisa Weiss (Graz, Austria)
      Higher gestational weight gain is associated with impaired wound healing and reduced expression of long non-coding RNA KLRK1-AS1 in neonatal endothelial progenitor cells

      P1.35 · Myrthe Willemars (Maastricht, Netherlands)
      Sex-specific re-balancing of cellular energy substrate metabolism to prevent pressure overload-induced hypertrophy

      P1.36 · Anna Zoccarato (London, United Kingdom)
      Constitutive activation of NRF2 induces glucose metabolic reprogramming in the heart and mediates cardio-protection via upregulation of the pentose phosphate pathway (PPP)

    • Poster Session II • Tuesday, 27 June • 13:00

      P2.1 · Jihun Ahn (Daejeon, South Korea)
      Three-year clinical outcomes of dual-drug-eluting cilotax stent and everolimus-eluting stents in acute myocardial infarction patients: results from the Korea Acute Myocardial Infarction Registry (KAMIR)

      P2.2 · Jihun Ahn (Daejeon, South Korea)
      Comparison of the safety and the efficacy between high-intensity statin therapy and dual lipid-lowering strategy with moderate-intensity statin therapy plus ezetimibe on the paitents who underwent percutaneous coronary intervention using drug eluting stent

      P2.4 · Martin Benedikt (Graz, Austria)
      Impact of the SGLT2-inhibitor Empagliflozin on inflammatory biomarkers in acute myocardial infarction– a post-hoc analysis of the EMMY trial

      P2.5 · Nikole Byrne (Graz, Austria)
      Nicotinamide mononucleotide supplementation attenuates atherosclerosis and diastolic dysfunction in western diet-fed Ldlr-/- mice

      P2.6 · Eva Correia (Rouen, France)
      Impact of curative perfusion with hypersosmolar lactate solution on cardiovascular dysfunction in a rat model of sepsis

      P2.7 · Miles De Blasio (Melbourne, Australia)
      Cardiac-selective adiponectin receptor gene therapy as a therapeutic target for cardiomyopathy in a mouse model of type 2 diabetes (T2D)

      P2.8 · Natacha Fourny (Brussels, Belgium)
      Contribution of protein O-GlcNAcylation to the development of cardiac dysfunction in obese diabetic mice

      P2.9 · Stefan Groß (Greifswald, Germany)
      Inverse associations of markers for cardiorespiratory fitness with high-sensitive CRP and white blood cell count are pronounced by metabolic syndrome status in the general population: Results from two cohorts of the Study of Health in Pomerania (SHIP-START-2, SHIP-TREND-0), Germany

      P2.10 · Helena Heilke (Greifswald, Germany)
      Individual LDL-c trajectories over time and all-cause mortality in Northeast Germany: Joint modeling of longitudinal and survival data over four follow-ups of the Study of Health in Pomerania (SHIP-START-0/1/2/3) in Germany

      P2.11 · Martijn Hoes (Maastricht, Netherlands)
      Novel autologous stem cell-derived cardiac tissues for translational research

      P2.12 · Soon Jun Hong (Seoul, South Korea)
      Comparison of effects of telmisartan and valsartan on neointima volume and atherosclerosis progression at 8 months after zotarolimus-eluting stent implantation in hypertensive type 2 diabetic patients

      P2.13 · Jae-Han Jeon (Daegu, South Korea)
      Vascular calcification is attenuated by activation of pyruvate flux

      P2.14 · Patrycja Kaczara (Cracow, Poland)
      Pharmacological regulation of platelet energy metabolism as a way to develop innovative antiplatelet therapies

      P2.15 · Ahmed Karoui (Orsay, France)
      Impact of Nicotinamide Riboside Kinase 2 overexpression and NAD precursor nicotinamide riboside treatment in response to endoplasmic reticulum stress induction in the heart

      P2.16 · Jaetaek Kim (Seoul, South Korea)
      Insulin signaling is critical for sinoatrial node maintenance and function

      P2.17 · Sung Joon Kim (Seoul, South Korea)
      Role of myofilament-associated nNOS for Ca2+ desensitization via troponin I phosphorylation in the right ventricular cardiomyocytes of rats

      P2.18 · Alice E. Knapton (Cambridge, United Kingdom)
      Amylin aggregation and suppression of mitochondrial respiratory capacity in the diabetic heart

      P2.19 · Soyeon Kwon (Seoul, South Korea)
      Extracellular vimentin induces ER stress in adipocytes

      P2.20 · Byung-Kwan Lim (Goesan-gun, South Korea)
      PDH activation reduced acute inflammation in CVB3-induced myocarditis

      P2.21 · Craig Lygate (Oxford, United Kingdom)
      What does homoarginine do in the heart? A hypothesis generating -omics study

      P2.22 · Matthew D. Martens (Edmonton, Canada)
      Reactive oxygen species modulator 1 (ROMO1) plays an obligate role in cardiomyocyte hypertrophy

      P2.23 · Lauriane Y. Michel (Brussels, Belgium)
      Protection against hypertrophic remodeling and oxidative stress by cardiac beta3-adrenergic receptors is mediated by NRF2 activation and the pentose phosphate pathway

      P2.24 · Bellina Mushala (Pittsburgh, PA, USA)
      GPR19 is an orphan receptor that mediates cardio-hepatic metabolic crosstalk in obesity

      P2.25 · Mariola Olkowicz (Cracow, Poland)
      Key role of 12-lipoxygenase in the regulation of vascular metabolism in atherogenic dyslipidaemia

      P2.26 · Julie Rennison (Cleveland, OH, USA)
      Complex I protein expression is increased in left atrium of patients in atrial fibrillation

      P2.27 · Matthew Rochowski (Stillwater, OK, USA)
      Cardiac-specific SERCA overexpression improves cardiac and systemic glucose metabolism during diabetes

      P2.28 · Michele Russo (Turin, Italy)
      Unravelling the metabolic aspects of doxorubicin-induced cardiotoxicity

      P2.29 · Sarah M Schumacher (Cleveland, OH, USA)
      Sex differences in cardiometabolic remodeling revealed by cardiac amino-terminal GRK2 peptide (βARKnt) regulation of AS160

      P2.30 · Ippei Shimizu (Osaka, Japan)
      Capillaries as a therapeutic target for heart failure

      P2.31 · Juhyun Song (Hwasun, South Korea)
      Lipocalin 2 controls neuronal cell via AKT signaling in a bile duct ligation mouse model

      P2.32 · Ivan Vosko (Graz, Austria)
      Distinct plasma ceramides predict cardiovascular mortality in diabetic and non-diabetic subjects with coronary artery disease

      P2.33 · Marie-Therese Weiser-Fuchs (Graz, Austria)
      Endothelium-modulating human milk oligosaccharides (HMOs) in maternal serum change during oral glucose tolerance test

      P2.34 · David Weissman (Würzburg, Germany)
      Cardiac fibroblast metabolism in Fabry cardiomyopathy: a window into pathogenesis and therapeutic targets

      P2.35 · Franziska Wittmann (Vienna, Austria)
      The influence of cardiovascular risk factors on preoperative vein graft quality in patients undergoing coronary artery bypass grafting